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Coleus and Cancer Metastases: Reserch has shown coleus to be a potent inhibitor of tumor colonization in mice. It is theoretically possible that coleus could be used in humans to prevent or inhibit tumor metastases.Many metastasizing tumor cell lines induce platelet aggregation both in vitro and in vivo. Upon aggregation, platelets release substances that promote tumor growth.Researchers have demonstrated forskolin's ability to block platelet aggregation via its stimulation of platelet adenylate cyclase and increase of intracellular cAME Agarwal and Parks gave 82 [micro]g forskolin to mice 30-60 minutes prior to injection with a highly metastatic melanoma cell line (B16 F10). Forskolin reduced tumor colonization in the lungs by 70 percent.

Forskolin is an extract from the roots of the Coleus forskohlii which directly activates the adenylate cyclase and raises cAMP(Cyclic adenosine Monophosphate) levels in a variety of tissues. One of the emerging clinical applications for C. forskohlii is for nutritional support in weight management. The rationale for this novel application has been derived from the lipolytic mechanism (a biochemical pathway to metabolize lipids in the body) of forskolin fueled by forskolin-generated cyclic amp and phosphorylation of hormone sensitive lipase (HSL). Forskolin used for improving lean body mass.